pPACK-SPIKE™ P1 Variant Spike Protein Lentivector Packaging Mix

Study the spike protein from SARS-CoV-2 Variant P1, a CDC variant of concern, with this packaging mix for lentivirus pseudotyped with the P1 spike protein

Based on SBI’s popular and highly cited pPACKH1 Packaging System
Uses codon-optimized SARS-CoV-2 “S” protein from variant P1 in place of VSV-G envelope protein
Spike protein mutations are L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F
Ideal for vaccine and antiviral efficacy studies under BSL2 conditions
Package any 3rd-generation lentivector reporter of your choice, including SBI’s popular LentiLabeler reporters

Cat. No.	Description	Size
CVD19-630A-1	pPACK-SPIKE P1, SARS-CoV-2 “S” Pseudotype – P1 Variant – Lentivector Packaging Mix	10 reactions
CVD19-635A-1	pPACK-SPIKE P1, SARS-CoV-2 “S” Pseudotype – P1 Variant – Lentivector Packaging Mix	25 reactions
CVD19-639A-KIT	pPACK-SPIKE P1 Combo Kit, includes Cat# CVD19-630A-1, plus PureFection Transfection Reagent (Cat# LV750A-1) and PEG-it Virus Concentration solution (Cat# LV810A-1)	1 kit

How It Works
pPACK-SPIKE is easy to use—simply co-transfect the pPACK-SPIKE Plasmids and your lentivector construct into 293TN producer cells or other lentiviral production cells, isolate pseudoviral particles with an optional concentration step, and conduct your studies.