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PH domain leucine-rich repeat-containing protein phosphatase 2
X2737P
100 ug
€359
Product description
PHLPP2 is a protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
Specifications
Applications
IHC, WB, ELISA
Host
Rabbit
Supplier
Exalpha, an Absolute Biotech Company
Shipping & storage
Shipping condition
Room Temperature
Storage temperature
-20°C
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PH domain leucine-rich repeat-containing protein phosphatase 2
X2737P
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PH domain leucine-rich repeat-containing protein phosphatase 2
X2737P
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