RABBIT ANTI CYCLIN D1

Rabbit anti Human cyclin D1 antibody recognizes the G1/S-specific cyclin D1, also known as B-cell CLL/lymphoma 1, CCND1, BCL-1 oncogene and PRAD1 oncogene.The protein encoded by CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of CCND1 is regulated positively by Rb. Mutations, amplification and overexpression of CCND1, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis (provided by RefSeq, Jul 2008).Rabbit anti Human cyclin D1 antibody detects a band of 36 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.