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NLRP3
SIH-604-5MG
5 mg
€232
Legenda image
Chemical structure of NLRP3, a NLRP3 inflammasome activation inhibitor (SIH-604). CAS # 256373-96-3. Molecular Formula: C20H23N2O5S ? Na.
Product description
NLRP3 (MCC950) was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-1(1). Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes(2). Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1? (IL-1?) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model)(3). Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome(4). A valuable new tool for exploring the pathophysiology of NLRP3.
Specifications
CAS number
256373-96-3
Supplier
Stressmarq
Shipping & storage
Shipping condition
Room Temperature
Storage temperature
-20°C
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SIH-604-5MG
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