ZBTB24 is a member of the Zinc finger and BTB domain-containing protein family. ZBTB24 consists of a BTB domain, an AT-hook DNA binding motif, and 8 C2H2-type zinc fingers. Mutations in the ZBTB24 gene are responsible for type 2 ICF (Immunodeficiency, Centromeric instability and Facial anomalies) syndrome, which shows hypomethylation of centromeric and pericentromeric satellite repeats. Because ZBTB24 localizes to pericentromeric heterochromatin, this protein may play an important role in formation and/or maintenance of pericentromeric heterochromatin.