Product description
Latent membrane protein 1 acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. It functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. It interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, LMP1 induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses.
Specifications
Applications
IHC
Host
Mouse
Clonality
Monoclonal
Clone
CS1, CS2, CS3, CS4
Supplier
Diagnostic BioSystems
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
2-8°C

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EBV Cocktail, CS1, CS2, CS3, CS4, Mouse, Monoclonal, Concentrate

Mob194-01

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EBV Cocktail, CS1, CS2, CS3, CS4, Mouse, Monoclonal, Concentrate

Mob194-01

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