Mouse Anti-Bovine GFAP

Mouse anti Bovine GFAP antibody, clone 2E1 recognizes glial fibrillary acidic protein, or GFAP, a class III intermediate filament. During development of the central nervous system, GFAP distinguishes astrocytes from other glial cells. It is involved in various cellular functions, such as cell structure and movement, cell communication and the functioning of the blood-brain barrier. It also plays a role in mitosis by adjusting the filament network present in the cell. Defects in GFAP are a cause of Alexander disease, a rare disorder of the central nervous system affecting mostly males. It is a progressive leukoencephalopathy resulting in mental and physical retardation, dementia, seizures and early death.Mouse anti Bovine GFAP antibody, clone 2E1 may be used in conjunction with Mouse anti Bovine GFAP antibody, clone 1B4 (MCA4733) and Mouse anti Bovine GFAP antibody, clone 4A11 (MCA4684) for increased sensitivity when used in immunohistology.