Anti-RCC1 (Human) mAb

The human RCC1 (Regulator of Chromosome Condensation) gene has been isolated as a gene that rescues tsBN2 mutation. The rcc1- phenotype is pleiotropic and includes G1 arrest, defects in mRNA splicing and mRNA transport. RCC1 is an abundant, highly conserved, chromatin-associated protein of 45 kDa which possesses an N-terminal region of 40 amino acid residues and an internal repeated domain in which about 60 amino acid residues are repeated seven times (RCC1 repeat). RCC1 is the principle mammalian guanine nucleotide exchange factor (GEF) for the nuclear G protein Ran, which GTPase activity is enhanced by GTPase-activating protein RanGAP located in the cytoplasm. RCC1 plays an important role in RNA transcription and processing, DNA replication, nuclear pore transport function and cell cycle regulation on Ran pathway. Epitope of this antibody is N-terminal domain (13-21 aa) of RCC1.