HUMAN ANTI AKT1

Human anti AKT1 antibody, clone AbD30769 recognizes AKT1, also known as RAC-alpha serine/threonine-protein kinase, protein kinase B alpha or Proto-oncogene c-Akt.
It belongs to the AGC kinase family (Brown and Banerji 2017). AKT activity is regulated downstream of receptor tyrosine kinases (RTKs) (Franke et al. 1995, Brown and Banerji 2017). Its substrates have a consensus phosphorylation motif: R-X-R-X-X-S/T-B (X is any amino acid and B denotes a preference for bulky hydrophobic residues) (Brown and Banerji 2017). A number of AKT substrates have been described including BAD (BCL2 associated agonist of cell death), FOXO (Forkhead Box), MDM2 (MDM2 oncogene), TSC2 (tuberous sclerosis 2), PRAS40 (proline rich Akt substrate), CDKN (cyclin-dependent kinase inhibitor) and GSK3? (glycogen synthase kinase beta) (Manning and Cantley 2007).
AKT is frequently activated in cancer (Manning and Toker 2017). In breast cancer, AKT isoforms play different roles during breast cancer progression (Riggio et al. 2017).