Human Anti-Human ADAP

Human anti Human ADAP antibody, clone AbD06348 recognizes the human molecular adaptor protein adhesion- and degranulation-promoting (ADAP). Adaptor proteins are essential components of the T-cell receptor (TCR) signaling cascade, regulating gene transcription and cytoskeletal re-organisation. ADAP is a 130 kDa molecule which interacts with several intermediates of the T-cell signaling cascade including SLP-76, FYN and VASP. The ADAP molecule is expressed on hematopoietic tissues and is reported to have multiple functions downstream of the TCR that promote optimal T lymphocyte response to antigen. In particular, ADAP is reported to function as a positive regulator of T-cell activation, LFA-1 integrin clustering following TCR ligation and T-cell adhesion.