Anti-Keratin K80 guinea pig polyclonal, serum

K80 is found in virtually all types of epithelia (stratified keratinizing-/ non-keratinizing-, hard-keratinizing- as well as non-stratified tissues, and cell cultures thereof). Throughout, K80 expression is related to advanced tissue or cell differentiation. However, instead of being part of the cytoplasmic IF network, K80 containing IFs are located at the cell margins close to the desmosomal plaques, where they are tightly interlaced with the cytoplasmic IF bundles abutting there. In contrast, in cells entering terminal differentiation, K80 adopts the "conventional" cytoplasmic distribution. In addition, KRT80 mRNA is subject to alternative splicing resulting in fully functional splice variant K80.1.