EPHB2 is a member of the Eph family of receptor tyrosine kinases that mediate neuro-developmental processes such as boundary formation, axon guidance, vasculogenesis and cell migration. Activated EPHB2 regulates the activity of the non-receptor tyrosine kinase Abl (1). EPHB2 is overexpressed in a number of tumors, particularly glioblastoma. In fact, EPHB2 overexpression leads to increased glioma cell migration and invasion (2).