Beta-Defensin-3 (HBD-3/MBD-3), affinity purified

The peptide sequences of HBD-3/MBD-3 used for immunisation contain very little consensus aa with any of the other human or mouse defensins. Human defensins are Cys-rich antimicrobial peptides which specifically react against Gram-negative bacteria. Originally defensins were isolated from hemolysates, but they can also be found on the cell surface of epithelia of the urogenital tract, lung, and trachea. In leukocytes defensins are stored in granules being released into phagolysosomes for the destruction of incorporated micro-organisms. Amino acid sequences of alpha-defensins 1-4 (HNP1-4) and beta-Defensins 1-4 (HBD1-4) are known. Mature Human Beta-Defensin-3 (HBD-3) shares app. 22% aa sequence homology with HBD-1. ß-defensin-3 of human and mouse origin, N-terminal fragments of HBD-3 and MBD-3, no cross-reactivity with other known ß-defensins or alpha-defensins.