Anti-PKR/EIF2AK2 (Human) pAb

The double-stranded RNA-activated protein kinase (PKR), also known as eukaryotic translation
initiation factor 2-alpha kinase 2 (EIF2AK2), is a ubiquitously expressed serine/threonine protein
kinase that plays a key role in the innate immunity response to viral infection in higher eukaryotes
and has also been implicated in several cellular signal transduction pathways. PKR also has been implicated in regulating other cellular functions such as differentiation, transcription, signal transduction, cell growth and apoptosis in the event of virus infection and other forms of cellular stress. It was reported that the activation of PKR in adipose and liver tissue is caused by obesity. In the absence of PKR, metabolic deterioration due to excess energy or nutrition is alleviated. These findings demonstrate that PKR is an important component of inflammation complex that responds to nutrients and organelle dysfunction.