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DKK3 Antibody
CSB-PA694792-100
100 ul
€272
Product description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease By similarity.
Shimizu K., Gene 282:151-158(2002).
Gray A.M., Genome Res. 13:2265-2270(2003).
Niehrs C., Oncogene 25:7469-7481(2006).
Shimizu K., Gene 282:151-158(2002).
Gray A.M., Genome Res. 13:2265-2270(2003).
Niehrs C., Oncogene 25:7469-7481(2006).
Specifications
Applications
WB, ELISA
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Supplier
CusaBio
Shipping & storage
Storage temperature
-20°C
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DKK3 Antibody
CSB-PA694792-100
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DKK3 Antibody
CSB-PA694792-100
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