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RUNX2 Antibody
CSB-PA14439A0Rb-50
50 ug
€152
Product description
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5\'-PYGPYGGT-3\', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
Specifications
Applications
WB, ELISA
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Supplier
CusaBio
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C
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RUNX2 Antibody
CSB-PA14439A0Rb-50
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RUNX2 Antibody
CSB-PA14439A0Rb-50
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