Anti-phospho-CDK1 (Tyr15)

Cell Division Control protein 1 (CDK1) is a highly conserved protein serine kinase. CDK1 is a catalytic subunit of the conserved eukaryotic protein kinase complex called that M-Phase Promoting Factor, which plays a key role in regulation of the cell cycle (1). CDK1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. The ability of CDK1 to exercise control over the cell cycle is dependent upon the phosphorylation of Tyr15 in cdc2 (2). CDK1 expression in brain has been linked to neurogenesis and apoptosis (3,4). In addition, CDK1 is a potential pharmaceutical target for prostate cancer therapy (5).