Rabbit Anti-Rat Alpha Synuclein (pSer129)

Rabbit anti Rat alpha synuclein (pSer129) antibody recognizes alpha synuclein when phosphorylated at serine 129. Alpha synuclein is a 140 amino acid, ~15 kDa protein seen predominantly in the neocortex, hippocampus, substantia nigra, thalamus and cerebellum. Its normal cellular function has not been definitively determined, but it is thought to be involved in the regulation of neuronal plasticity, dopamine neurotransmission and other membrane-associated processes at the presynaptic terminal.Alpha synuclein is normally a soluble, unfolded protein, but it can aggregate at high concentrations to form insoluble fibrils which, in association with other proteins such as ubiquitin, neurofilament protein and alpha B crystalline, form Lewy bodies. Lewy bodies are a hallmark pathological feature of Parkinson's disease and other neurodegenerative diseases. Alpha synuclein has several possible phosphorylation sites, serine 129 in particular can be phosphorylated by G-protein-coupled receptor kinases and this phosphorylation promotes formation of alpha synuclein filaments, with hyperphosphorylation of serine129 seen in Lewy bodies.