Rabbit Anti-ORAI1 (C Terminal)

Rabbit anti Human ORAI1 antibody recognises human ORAI1, also known as Transmembrane protein 142A (TMEM142A), a 32.7 kDa multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca²⁺ entry through Ca²⁺ release-activated Ca²⁺ (CRAC) channels. CRAC channels are the main pathway for Ca²⁺ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI1 is a four- transmembrane spanning protein that is an essential component of CRAC. ORAI1 functions as a highly selective Ca²⁺ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca²⁺ sensor. Defective ORAI1 in humans is the cause of one form of hereditary severe combined immune deficiency (SCID), which results in ablated T-cell Ca²⁺ entry.Rabbit anti Human ORAI1 antibody ( AHP1494) is not expected to cross react with either ORAI2 or ORAI3.