Rabbit Anti-Rat MEK 5 (pSer311 Thr315)

Rabbit anti Rat MEK 5 (pSer311/pThr315) antibody recognizes MAPK/ERK kinase 5 (MEK 5), also known as dual specificity mitogen-activated protein kinase kinase 5 (MAPKK 5), when phosphorylated at serine 311 and threonine 315.MEK5 is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family, which acts as a key regulator in a mitogen-activated protein (MAP) kinase cascade, and hence growth factor-induced cellular stimulation. MEK5 exists in naturally occurring MEK5alpha and MEK5beta splice variants, the former of which is known to specifically activate/regulate MAPK7/ERK5/BMK1, whilst the latter may act as a suppressor of MAPK7 activation. Activation of MEK5 itself is regulated by upstream MAP3K3/MEKK3, and phosphorylation of MEK5 at both the serine 311 and threonine 315 sites has been implicated in cell proliferation.