A83-01

Potent and selective ALK4, 5 and 7 inhibitor (1,2). IC50=45, 12, 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGF? (2). Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency (3). Together with AMI-5 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts (4). Active in rat models. Cell permeable