Apolipoprotein A-V, FLAG Tag, HEK, human recombinant (rHuAPO-A5-FLAG-HEK)

Human recombinant APOA5 Flag-Tagged fusion protein is a 40.1 kDa protein containing 354 amino acid residues of the human APOA5 and 11 additional amino acid residues of flagTag. ApoA5 is an important regulator of serum triglyceride concentrations. An ApoA5 mouse nock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. Furthermore, peroxisome proliferators-activated receptoragonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. There is very little known about ApoA5 protein in human serum. Lately, it was established that ApoA5 is present in the human serum and it can be detected by polyclonal antibodies against both the HN2 and COOH termini, but at much lower concentration than other apolipoproteins.