C22 Glucosylceramide-d4 (d18:1/22:0-d4)

C22 Glucosylceramide-d4 is intended for use as an internal standard for the quantification of C22 glucosylceramide (Item No. 23210) by GC- or LC-MS. C22 Glucosylceramide is an endogenous glucosylceramide.{41137,41138,41139} Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide (Item No. 16983), as well as oligoglycolipids and gangliosides. Phospholipase A2 (PLA2) type XIIA knockdown increases C22 glucosylceramide expression in rat brain.{41139} It is also increased in the brain, but not the liver or spinal cord, of mice fed a methionine-restricted diet.{41138} In human athletes, plasma levels of C22 glucosylceramide increase during exercise and return to basal levels during recovery.{41137} As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 2216]