Human IL-33 Cytokine domain Detection Kit

Interleukin-1 (IL-1) family, such as IL-1?/? and IL-18, has important functions in host defense, autoimmune disease and inflammation. IL-33, a member of the IL-1 family of cytokine, is a ligand for the IL-1 receptor families ST2 (IL-33R? chain) and IL-1RAcP, which induces the production of Th2-associated cytokines from mast cells and basophils. IL-33/ST2 signaling results in activation of NF-?B or AP-1 induces Th2 associated cytokines, IL-4, IL-5 and IL-13. IL-33 is also described as a Nuclear Factor from High Endothelial Venules (NF-HEV) and as DVS27. IL-33 is localized in the nucleus of human endothelial and epithelial cells that binds to chromatin via a homeodomain and nuclear localization signal in its N-terminus. IL-33 is a dual functional protein that may function as both a proinflammatory cytokine and a nuclear factor with transcriptional regulatory properties. Recent many studies reported that IL-33 is expressed in various organs and cells. Furthermore, IL-33 has been linked to many diseases, including rheumatoid arthritis, atopic dermatitis, asthma, pollinosis, atherosclerosis, cardiovascular diseases and autoimmune diseases. “Human IL-33 Cytokine domain Detection Kit” is a reagent for measuring human IL-33 specifically with ELISA, not for measuring mouse IL-33.