Ks 2.342.7.4 represents an excellent marker to study terminal epidermal differentiation. The mab is reactive with epidermal cells in uppermost suprabasal layers including scalp, foot and sole. It recognizes individual cells within epidermis of tongue and mamille (co-localization with keratin K10). It is also reactive on hyperkeratosis of diverse viral and genetic origin.The mab does not react with palate keratin K76.
The actual clone designation of this antibody is Ks2.342.7.4. The 2 last digits refer to the passage number of the cultured cells of clone Ks2.342. Passage 7.1 is used up.
Reactive polypeptide (specificity): Basic human keratin K2 (MW 65,852; formerly also designated cytokeratin 2e).
Antigen recognized in species:
bovine: calf hoof epidermis, snooze epithelium; negative with tongue epithelium;
Mouse/rat: heterogenously on foot sole epidermis only,negative with epidermis of other body sites.