8G1 specifically reacts with the 515 kDa a-chain of human LRP/a2MR which is expressed in a restricted spectrum of cell types (Herz & Strickland, 2001). A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurones and astrocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in atherosclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).
Herz J and Strickland DK: LRP, a multifunctional scavanger and signaling receptor. J. Clin. Invest. 108, 779-784 (2001).