Interleukin-6Ra/CD126 Rabbit Monoclonal Antibody

Interleukin-6R? (IL-6R?), also known as CD126, is a type I cytokine receptor.{16580} It is composed of an immunoglobulin-like domain, a cytokine-binding domain, a transmembrane domain, and a cytoplasmic domain and forms a heteromeric complex with IL-6 and gp130, which is the signal transducing subunit of the IL-6R that primarily acts through the JAK/STAT3 pathway.{65404} IL-6R? is expressed in hepatocytes and monocytes and is localized to the plasma membrane but also exists as a soluble form (sIL-6R?) that is primarily generated via proteolytic cleavage of membrane-bound IL-6R?, but can also be formed via alternative splicing.{65405,65406,65407} Binding of IL-6 to membrane-bound IL-6R?, known as classical signaling, upregulates the synthesis of acute phase proteins, induces lipolysis in the liver, and induces the differentiation of T and B cells and is primarily anti-inflammatory.{46747,46748} Trans-signaling consists of IL-6 binding to sIL-6R, which has various pro-inflammatory effects. Knockdown of IL6R increases sensitivity to tamoxifen in breast cancer cells.{65408} Formulations containing chimeric anti-IL-6R? monoclonal antibodies have been used in the treatment of rheumatoid arthritis, idiopathic arthritis, giant cell arteritis, cytokine release syndrome, and COVID-19. Cayman's Interleukin-6R?/CD126 Rabbit Monoclonal Antibody (Clone 033) can be used for ELISA (capture) and flow cytometry (FC) applications.