VE-Cadherin/CD144 Monoclonal Antibody

VE-cadherin, also known as CD144, is a type II classical cadherin and member of the cadherin superfamily of calcium-dependent cell adhesion molecules.{57323} It is composed of an N-terminal signal peptide, a pro-peptide, five extracellular cadherin repeats that bind to homotypic cadherins, a transmembrane domain, and a cytoplasmic tail that interacts with the cytoskeleton. VE-cadherin is endothelial cell-specific and is localized to intracellular junctions where it participates in vascular structure assembly.{7068,7069,7071} An anti-VE-cadherin antibody in combination with an anti-CD31 antibody inhibits tube formation in human umbilical vein endothelial cells (HUVECs).{7070} Knockout of Cdh5, the gene encoding VE-cadherin, in mouse embryonic stem cells prevents the formation of vessel-like structures in 11-day-old embryoid bodies.{7069} VE-cadherin is overexpressed in melanoma and breast cancer and is positively correlated with poor prognosis.{66126} Cayman's VE-Cadherin/CD144 Monoclonal Antibody can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.