Clusterin Monoclonal Antibody

Clusterin is a secreted heterodimeric glycoprotein.{19214} It is proteolytically processed to remove a signal peptide and cleave the ? and ? chains.{19214,58474} This cleavage creates small- and medium-sized isoforms found in the nucleus or cytosol and mitochondria, respectively, and a large-sized isoform composed of ?- and ? chains linked via disulfide bonds near the center that is secreted outside the cell.{58474} Clusterin is ubiquitously expressed in tissues and found in physiological fluids. It is a multifunctional protein involved in a wide range of processes, including immune modulation, autophagosome formation, apoptosis, and extracellular matrix remodeling, among others.{58475} Clusterin is upregulated by cellular stress and acts as an extracellular chaperone and scavenger to prevent protein aggregation. SNPs in CLU, the gene encoding clusterin, are associated with a higher rate of cognitive decline in patients with mild cognitive decline or Alzheimer's disease.{58476} Clusterin is also associated with inflammatory and cardiovascular diseases, where it has either protective or detrimental effects.{58474} Cayman's Clusterin Monoclonal Antibody can be used for flow cytometry (FC), ELISA, immunocytochemistry (ICC), immunofluorescence (IF), and Western blot (WB) applications.