FcyRI/CD64 Rabbit Monoclonal Antibody

CD64, also known as high-affinity immunoglobulin ? receptor I (Fc?RI), is a transmembrane glycoprotein that binds the Fc region of IgG.{67216} It is composed of a ligand-binding ?-chain, which contains three extracellular Ig-like domains, a transmembrane region, and a cytoplasmic domain, and two ?-chains, which contain immunoreceptor tyrosine-based activation motifs (ITAMs) that mediate signal transduction.{67217,67218,67219} CD64 is constitutively expressed in myeloid cells, including monocytes and macrophages, but can be induced in neutrophils in response to IFN-? or G-CSF.{67220,67218} It is involved in phagocytosis, cytokine release, antibody-dependent cell-mediated cytotoxicity (ADCC), and antigen presentation to primed T cells.{67216,67221} Mouse CD64 selectively forms immune complexes with IgG2a, whereas human CD64 forms immune complexes with IgG1, IgG3, and IgG4.{67216,67222} Knockout of Fcgr1, the gene encoding CD64, inhibits clearance of B. pertussis infection in mice.{67216} Increased serum levels of CD64 are associated with sepsis.{55736} Cayman’s Fc?RI/CD64 Rabbit Monoclonal Antibody can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.