2,3,5,4'-Tetrahydroxyl-diphenylethylene 2-O-B-D-Glucoside

2,3,5,4’-Tetrahydroxyl-diphenylethylene 2-O-B-D-glucoside (TSG) is a stilbene glucoside that has been found in P. multiflorum and has diverse biological activities.{64070,64071,64072,64073} It scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 40 µM).{64070} TSG inhibits doxorubicin-induced apoptosis, loss of mitochondrial membrane potential, and generation of reactive oxygen species (ROS) in mouse cardiomyocytes.{64071} Ex vivo, TSG (30, 60, and 120 mg/kg) increases acetylcholine-induced relaxation of, and nitric oxide (NO) levels in, aortic rings isolated from a rat model of diet-induced atherosclerosis.{64072} In vivo, TSG (15 and 40 mg/kg) reduces infarct area and neuronal apoptosis in a mouse model of ischemia and reperfusion injury induced by middle cerebral artery occlusion (MCAO).{64073}