MR1 Monoclonal Antibody (Clone 2H7)

Major histocompatibility complex (MHC) class I-related gene protein (MR1) is a non-polymorphic MHC class Ib antigen-presenting cell surface molecule that is required for T cell receptor-mediated activation of mucosal-associated invariant T (MAIT) cells.{60473,60472} It is composed of ?1 and ?2 domains, which form an antigen-binding pocket, and an ?3 domain that interacts with ?2-microglobulin.{60472} MR1 mRNA is ubiquitously expressed and, following translation, MR1 protein is localized to the endoplasmic reticulum in a partially folded state. Upon binding of a riboflavin-derived microbial antigen, MR1 undergoes a conformational change and translocates to the cell surface where it induces MAIT cell activation via an interaction with the MAIT cell T cell receptor and activates various immunomodulatory effects, including cytokine release, initiation of adaptive immune responses, and promotion of tissue repair.{60474} Cayman’s MR1 Monoclonal Antibody (Clone 2H7) can be used for ELISA, flow cytometry (FC), immunoprecipitation (mass spec confirmed) (IP), and Western blot (WB) applications. The antibody recognizes MR1 at approximately 39 kDa from human samples.