Aurora B Kinase (N-Term) Rabbit Monoclonal Antibody

Aurora B kinase is a serine/threonine protein kinase involved in the regulation of mitosis.{59636} It is composed of an N-terminal regulatory domain containing KEN- and A-box motifs, which regulate degradation of Aurora B, and a C-terminal catalytic domain containing an activation loop and a D-box, which also regulates Aurora B degradation. Aurora B kinase is ubiquitously expressed with the highest expression at the G2/M phase of the cell cycle and the highest activity during mitosis.{59637} It localizes to the nucleus, where it is a component of the chromosome passenger complex (CPC).{59638} Aurora B kinase is involved in the modification of chromatin and centromeres by phosphorylating histone H3 and centromere protein A (CENP-A), respectively, during mitosis.{59636,59638} It is also involved in chromatid separation, by phosphorylating mitotic centromere-associated kinesin (MCAK) to stabilize kinetochore-microtubule attachments, and in the regulation of cytokinesis.{59636} AURKB, the gene encoding aurora B kinase, is overexpressed in a variety of cancers and its expression levels are positively correlated with disease severity, poor prognosis, and lower overall survival.{59637} Cayman's Aurora B Kinase (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.