Histone H2BS14Ph Monoclonal Antibody

Histone H2B is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains a histone fold domain with a C-terminal ?-helix that facilitates nucleosome interactions and chromatin compaction, as well as an unstructured N-terminal tail that extends outside of the nucleosome core, both of which are subject to various post-translational modifications (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation.{57056,58056,58057} Phosphorylation of histone H2B at serine 14 (H2BS14Ph) is associated with DNA damage and induces apoptotic chromatin condensation.{60047,60048} H2BS14Ph also correlates with class switch recombination and somatic hypermutation in germinal center B cells.{60049} Cayman’s H2BS14Ph Monoclonal Antibody can be used for ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.