Histone H3T3Ph Monoclonal Antibody

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Phosphorylation of histone H3 at threonine 3 (H3T3Ph), catalyzed by the serine/threonine protein kinase haspin, is involved in the localization of the chromosomal passenger complex (CPC) at centromeres during mitosis and chromatin condensation during meiosis.{57288,57289} Cayman’s Histone H3T3Ph Monoclonal Antibody can be used for ELISA, immunocytochemistry (ICC), immunohistochemistry (IHC), multiplex-based assay, and Western blot (WB) applications.