Histone H3K9Ac Monoclonal Antibody

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Acetylation of histone H3 at lysine 9 (H3K9Ac) is associated with active gene transcription and can recruit the super elongation complex to chromatin through direct binding with the AF9 and ENL subunits.{47278,47279} It increases at the IFN-? promoter in HeLa cells upon infection with Sendai virus.{47280} Acetylation of histone H3 at lysine 9 decreases following induction of DNA damage in HeLa and U2OS cells.{47281} Cayman's Histone H3K9Ac Monoclonal Antibody can be used for chromatin immunoprecipitation (ChIP), ELISA, immunocytochemistry (ICC), immunohistochemistry (IHC), multiplex-based assay, and Western blot (WB) applications.