a-Tubulin Monoclonal Antibody

?-Tubulin is a cytoskeletal protein and constituent of microtubules, a cytoskeletal assembly that has roles in a variety of cellular processes, including cell motility, division, differentiation, and intracellular transport.{57121} ?-Tubulin is highly conserved in eukaryotes and expressed in a cell- and isotype-specific manner.{57122} There are eight human ?-tubulin isotypes that consist of an N-terminal domain, which binds GTP and is required for microtubule self-assembly, and a variable C-terminal tail, which contains interaction sites for microtubule-associated proteins (MAPs) and is subject to a variety of post-translational modifications that regulate microtubule function and stability.{57123,57124,57121,57125} Cayman's ?-Tubulin Monoclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications. The antibody recognizes ?-tubulin at approximately 50 kDa.