AITRL His Recombinant Protein

Source : Escherichia Coli. AITRL Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain (aa 50-177) containing a total of 137 amino acids & having a molecular mass of 15.6kDa. The AITRL protein is fused to a 9 aa His Tag at C-terminus & purified by proprietary chromatographic techniques. Osteostat is the cytokine that binds to TNFRSF18/AITR/GITR & is important for interactions between activated T-lymphocytes & endothelial cells & may modulate T-lymphocyte survival in peripheral tissues. Osteostat is expressed at high levels in the small intestine, ovary, testis, kidney & endothelial cells after stimulation by lipopolysaccharides.Osteostat protein is detectable in human microvascular EC & is highly up-regulated by IFN-alpha & IFN-beta. Osteostat inhibit differentiation of osteoclasts from monocytic precursor cells. Osteostat suppresses the early stage of osteoclastogenesis via inhibition of macrophage colony-stimulating factorinduced receptor activator of NF-kappaB (RANK) expression in the osteoclast precursor cells. Osteostat does not inhibit lipopolysaccharide-induced RANK expression in monocytes & dendritic cells, or activation-induced RANK expression in T cells. Osteostat is a novel regulator of osteoclast generation & substantiate the major role played by the endothelium in bone physiology.