SARS-CoV/SARS-CoV-2 Nucleocapsid Protein Rabbit Monoclonal Antibody (Clone 019)

Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 nucleocapsid proteins are encoded by the N gene in SARS-CoV and SARS-CoV-2 RNA.{53462,62041} SARS-CoV and SARS-CoV-2 are members of the Betacoronavirus genus of viruses that have approximately 79% sequence identity and share 27 T cell epitopes in common.{53459,53461,49555} The SARS-CoV-2 nucleocapsid protein has greater than 90% similarity to the SARS-CoV nucleocapsid protein and contains two unique B cell epitopes and two T cell epitopes that are structurally stable, non-allergenic, and induce production of IFN-?.{62041,49555} SARS-CoV and SARS-CoV-2 nucleocapsid proteins package the viral RNA into a helical ribonucleoprotein complex (RNP), which is a template for viral replication, and are integral for viral self-assembly and involved in regulation of the host cell cycle.{62041,53460} SARS-CoV and SARS-CoV-2 are the causative agents of SARS and COVID-19, respectively, both of which are primarily respiratory illnesses characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.{53461,55257,55258} Cayman's SARS-CoV/SARS-CoV-2 Nucleocapsid Protein Rabbit Monoclonal Antibody (Clone 019) can be used for ELISA, immunohistochemistry (IHC; paraffin), and Western blot (WB) applications. This recombinant antibody recognizes nucleocapsid protein at 45.6 kDa from SARS-CoV, SARS-CoV-2, and several SARS-CoV-2 Omicron and Delta subvariants.