Vilanterol-d4 (triphenylacetate)

Vilanterol-d4 is intended for use as an internal standard for the quantification of vilanterol (Item No. 20702) by GC- or LC-MS. Vilanterol is a long-acting agonist of the B2-adrenergic receptor (B2-AR).{32608} It selectively induces cAMP accumulation in CHO cells expressing the B2-AR over the B1- and B3-ARs (EC50 = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine (Item No. 33828) in guinea pigs when administered via nebulization (EC50 = 30 µM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.