Atropine-d5

Atropine-d5 is intended for use as an internal standard for the quantification of atropine (Item No. 12008) by GC- or LC-MS. Atropine is a tropane alkaloid that has been found in A. belladonna and acts as a non-selective, competitive antagonist of muscarinic acetylcholine receptors (KBs = 0.16-1.26 nM for the M1-M5 receptors).{46975,22121} Atropine increases firing of the sinoatrial node and conduction through the atrioventricular node of the heart, opposes the actions of the vagus nerve, blocks acetylcholine receptor sites, and decreases bronchial secretions.{22120} Formulations containing atropine have been used to induce mydriasis for ophthalmological exams and in the treatment of cardiac arrest and organophosphate pesticide or muscarinic mushroom poisoning.