Nimodipine-d7 is intended for use as an internal standard for the quantification of nimodipine (Item No. 14573) by GC- or LC-MS. Nimodipine is an inhibitor of L-type voltage-gated calcium (Cav) channels.{28544} It is selective for Cav1.2 over Cav1.3 channels (IC50s = 0.139 and 2.7 uM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 uM.{28544,53840} Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips.{53841} It increases cerebral blood flow in anesthetized dogs when administered sublingually at doses ranging from 0.01 to 1 mg/kg. Nimodipine decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53842}
Specifications
Size
500 ug
CAS number
1246815-36-0
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C