Suplatast is an antiallergic agent.{53624,53625} It inhibits IL-4 and IL-5 production in conalbumin-stimulated D10.G4.1 murine T helper 2 (Th2) cells in a concentration-dependent manner.{53624} Suplatast (100 mg/kg) inhibits ovalbumin-induced increases in eosinophil and total cell numbers, as well as IL-4, IL-5, and IL-13, but not IFN-y, levels in bronchoalveolar lavage fluid (BALF) in an ovalbumin-sensitized mouse model of asthma.{53625} It also inhibits ovalbumin-induced increases in ovalbumin-specific IgE in serum and bronchial hyperresponsiveness to methacholine in the ovalbumin-sensitized mouse model of asthma.
100 mg
CAS number
Cayman Chemical
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