Methylophiopogonanone B

Methylophiopogonanone B is an isoflavone that has been found in O. japonicus and has diverse biological activities.{55050,55053,55051,55052} It increases Rho activity in normal human epidermal melanocytes (NHEMs) when used at a concentration of 1 µM.{55050} Methylophiopogonanone B inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia with an IC50 value of 7.8 µM.{55053} It reduces hydrogen peroxide-induced production of reactive oxygen species (ROS), apoptosis, and decreases in superoxide dismutase (SOD) activity in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 40 and 50 µM.{55051} It is cytotoxic to SMMC-7721 and HeLa cancer cells (IC50s = 34.6 and 6 µg/ml, respectively).{55052}