IL-6 is a cytokine with roles in both the initiation and resolution of inflammatory responses.{46747,46748} IL-6 is produced in response to an inflammatory event, induces recruitment of neutrophils to the site of inflammation, and signals through the membrane-bound IL-6 receptor (IL-6R) to upregulate the synthesis of acute phase proteins, lipolysis in the liver, and induced differentiation of T and B cells. Following initiation of this classical signaling pathway, a soluble form of IL-6R (sIL-6R) is released from neutrophils to promote recruitment of monocytes and macrophages, induction of fever via IL-6 action in the hypothalamus, and production of anti-inflammatory M2 macrophages to initiate tissue repair. Production of IL-6 is dysregulated in various chronic inflammatory diseases, including rheumatoid arthritis, Castleman disease, polymyalgia rheumatica, and giant cell arteritis.{46749} It also induces tumor growth and metastasis via activation of JAK/STAT signaling.{46750} Cayman’s IL-6 (human, recombinant) protein can be used for ELISA, Western blot, and cell-based assay applications. Post-translational modifications such as glycosylation may retard receptor electrophoretic migration such that the protein signal may be detected between 20 and 26 kDa.
Specifications
Applications
WB, ELISA
Size
100 ug
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-80°C