Betulinic Acid methyl ester

Betulinic acid methyl ester is a lupane-type triterpenoid and an esterified version of betulinic acid (Item No. 11686) that has been found in Helicteres hirsuta and has diverse biological activities.{52302,52303,52304,52305,52306} It inhibits HIV-1 reverse transcriptase (IC50 = 11 ?M).{52302} Betulinic acid methyl ester is active against L. braziliensis and T. cruzi (IC50s = 69.9 and 93.3 ?M, respectively).{52303} It induces melanogenesis in (EC50 = 2.5 ?M) and inhibits the growth of B16 2F2 melanoma cells in vitro (IC50 = 4.9 ?M).{52304} Betulinic acid methyl ester is cytotoxic to SK-LU-1, HepG2, HeLa, SK-MEL-2, and AGS cells (IC50s = 60.84, 77.43, 80.17, 66.17, and 69.94 ?g/ml, respectively).{52305}