HIF-1a (C-Term) Blocking Peptide

To be used in conjunction with Cayman’s HIF-1? Polyclonal Antibody (Item No. 10006421) to block protein-antibody complex formation during immunochemical analysis of HIF-1?. HIF-1? is a transcription factor that accumulates under low-oxygen conditions.{10948,11044} Following hypoxic stimulus and cytoplasmic accumulation, HIF-1? migrates to the nucleus where, with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however HIF-1? overexpression in cancer cells promotes tumor survival.{11044,9833,9834,9835,10695} HIF-1? is an EPAS-1 family member with phosphorylation dependent activities. HIF-1? will migrate to the apparent molecular weights of 110-125 kDa (by SDS-PAGE) depending on phosphorylation status.{11043,10898}