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Anti-CD49d / Integrin alpha 4 Monoclonal Antibody (Clone:9F10)
30-1085
0,1 mg
€614
Product description
CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.
Specifications
Applications
FC, IHC-Fr, FUNC
Host
Mouse
Clonality
Monoclonal
Clone
9F10
Isotype
Mouse IgG1
Supplier
Abeomics
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
2-8°C
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Productname
Anti-CD49d / Integrin alpha 4 Monoclonal Antibody (Clone:9F10)
30-1085
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Productname
Anti-CD49d / Integrin alpha 4 Monoclonal Antibody (Clone:9F10)
30-1085
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
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