3-O-methyl Quercetin

3-O-methyl Quercetin is a flavone that has been found in C. balchaschensis and has diverse biological activities.{63233,63234,63235,63236} It is an inhibitor of B-secretase (IC50 = 6.5 µM).{63233} It scavenges DPPH (Item No. 14805) radicals and superoxide anions in cell-free assays (IC50s = 14.17 and 17.39 µM, respectively), as well as inhibits lipid peroxidation and hydrogen peroxide-induced neuronal cell death in primary rat cortical cells (IC50s = 19 and 3.5 µM, respectively).{63234} 3-O-methyl Quercetin inhibits poliovirus RNA synthesis in infected HeLa cells when used at concentrations of 2 and 20 µg/ml.{63235} It also inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 3.8 µM) and reduces LPS-induced increases in the levels of inducible nitric oxide synthase (iNOS) in BV-2 microglia.{63236}