CGRP Monoclonal Antibody (Clone 4901)

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide.{41395} It exists in two major forms that share greater than 90% sequence homology, ?-CGRP that is produced by alternative RNA splicing of the calcitonin gene CALCI and ?-CGRP that is encoded by CALCII in humans. CGRP is primarily expressed in A and C? fibers and exhibits perivascular localization but is also expressed in keratinocytes and endothelial progenitor cells.{41395,53682} CGRP binds to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) and has roles in efferent function, nociception, and vasodilation. Levels of CGRP are increased in various pain states, including migraine. It also suppresses TNF-?, increases fibroblast motility and extracellular matrix synthesis, and induces Schwann cell proliferation to facilitate peripheral nerve regeneration following injury.{53683} Cayman’s CGRP Monoclonal Antibody (Clone 4901) can be used for ICC applications.